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Article Type

Article

Abstract

Irritable Bowel Syndrome (IBS) is a common gut disorder that affects approximately 11% of the global population and negatively affects the quality of life of patients and imposes a significant socioeconomic burden. A control-based study was conducted on 42 Iraqi patients with IBS who presented at private clinics for gastrointestinal diseases (GIDs), along with 20 healthy individuals matched in age and gender to act as a control group. The study aimed to determine the frequency of IBS among Iraqi patients, as well as the influence of biomarkers on the disease's initiation, type, and severity such as IL-1ß, anti-Cytolethal distending toxin B (Anti-CdtB), and histamine. The results showed that the constipation subtype of IBS is the most frequent among patients, with females constituting the majority of IBS patients with a female-to-male ratio of about 2.23:1. The levels of IL-1ß, anti-CdtB, and histamine are significantly elevated in the serum of IBS patients when compared to their levels in the control group. In the patients' group, anti-CdtB showed a significant positive correlation with the level of histamine, while the correlations between anti-CdtB and IL-1ß, as well as between histamine and IL-1ß, are not significant. It can be concluded that anti-CdtB may act as a key player in IBS pathogenesis after disrupting gut microbiota, which requires further investigation.

Keywords

IBS, IL-1ß, Anti-CdtB, Histamine

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