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Article Type

Article

Abstract

Everywhere in the globe, kidney illness is becoming more common, and there is no medication that can stop the progression of chronic kidney disease to end-stage renal disease, which is extremely expensive. Diabetes, kidney stones, accidents, and bleeding are the main contributors to kidney disease. The study was designed as a case control study. The study was involved (80) participants, only (36) were involved in this study and divided into two groups patients with nephropathy (23) and diabetic nephropathy (13) with age (20-65years) and BMI (19 -29 kg/m2). All these patients were diagnosed by nephrologist conducted in nephrology Clinic at al-Emma al Sadeq Hospital and AL Hila teaching hospital in Hila city and Department of biochemistry in Collage of Medicine at University of Babylon from October 2022 to March 2023. In current study measured the glucose, urea, creatinine, GFR, BTP, LFABP, salivary hydroxyl and amide bands. The glucose, urea and creatinine measured by caloric spectrophotometry (CECIL CE2021), the BTP and LFABP measured by Elisa (biotekELx50) also salivary hydroxyl and amide bands measured by FT-IR (Bruker) Tensor27. The study showed non-significant differences for (age, and BMI) between patients with nephropathy and diabetic nephropathy. Also in the current study the result show a significant differences of glucose, creatinine and GFR and a non-significant of urea. On the other hand the result show non-significant increase of BTP, LFABP and salivary hydroxyl and amide bands between studied groups. In conclusion, the BTP and LFABP are linked with GFR and are thought to be indicated presence of renal impairment regardless of glucose effect.

Keywords

Nephropathy (NP), Diabetic nephropathy (DNP), Beta trace binding protein (BTP), Liver fatty acid binding protein (L-FABP), Salivary hydroxyl and amide.

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