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Article Type

Article

Abstract

Endstage renal disease (ESRD) usually comes on by diabetic nephropathy (DN) and is one of the most dreaded chronic microvascular complications of diabetes. The objective of this study is to provide an overview of the DN-biomarker landscape with a particular emphasis on new approaches that improve the sensitivity of biomarkers for identifying patients who will develop DN or who are at risk of developing ESRD. This study was designed as a case-control study. 120 individuals were involved, divided into three groups: a control group diabetic without nephropathy, Early stage and end stage of nephropathy, 40 patients were taken for each group identical in gender (20 male and 20 female). All the diabetic patients included in the current study were diagnosed by nephrologists at the nephrology Clinic at Al-Emam Al Sadeq Hospital in Hila city and Department of Biochemistry in College of Medicine at University of Babylon from October 2022 to March 2023. C-reactive protein was determined by immune-detection method and Vit. D3 by chemiluminescence immunoassay. The results of the current study revealed a significant increase in serum CRP among diabetic nephropathy patients when compared to control and a significant decrease of serum vitamin D3 in diabetic nephropathy patients than control.

Keywords

Diabetic nephropathy (DN), Vitamin D, Diabetic complications, CRP

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