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Article Type

Article

Abstract

Most people throughout the world suffer from iron deficiency anemia (IDA). The morbidity rate is relatively high for such a complicated illness. Importantly, it has been identified that the aquaporin-1 polymorphism rs10244884 plays a critical role in iron homeostasis in the human body. The rs10244884 (T > C) polymorphism is significantly associated with iron levels and a variety of blood factors, leading to iron deficiency anemia (IDA). Venous blood samples were collected from (100) people in this analytical (case and control) investigation, including (50) patients with iron deficiency anemia and (50) healthy volunteers as a control group. The following parameters were measured: hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and mean corpuscular hemoglobin (MCH). The AQP1 C/T polymorphism was identified by polymerase chain reaction (PCR) after genomic DNA was extracted through the salting-out procedure. Finally, the AQP1 C/T polymorphism was shown to have a significant association with IDA prevalence among Iraqi patients in Baghdad city. Furthermore, we found significant associations between AQP1 C/T genotypes and the medians of Hb, MCV, MCHC, and MCH in IDA patients compared to healthy controls. However, neither the healthy nor the mutant gene showed any discernible changes in IDA patients.

Keywords

IDA, Hemoglobin, AQP1, rs10244884 (T>C)

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