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Article Type

Original Study

Abstract

Introduction: Diabetes, particularly when uncontrolled for an extended length of time, was already related with a higher risk of complications and progression of both macrovascular and microvascular problems. Diabetic nephropathy is one of the complications of diabetes can be a result from micro vascular effect of diabetes, kidney disease can occur in both type one or type two diabetes patients kidney disease usually affects young and middle-aged patients. Kidney injury molecule and Nephrin is a biomarkers used to diagnosis of early biomarkers in diabetic nephropathy Objective: The aim was effectiveness of KIM-1 and nephrin for diagnosis of diabetic kidney disease and compares with other markers as blood urea and s.cr and eGFR .Materials and methods: A case-control study included 90 participant that divided into three groups: 30 diabetic mellitus DM ,30 diabetic nephropathy (DN) , and 30 healthy control groups, the study starter in November 2023 until March 2024. Laboratory tests were performed on all patients and controls. These included measurements of fasting blood sugar, blood urea, serum creatinine, and by full automated analyzer and KIM-1, and Nephrin by ELISA method. Results: The biomarkers KIM-1, Nephrin showed high significant increase in diabetic nephropathy group, and the correlation between KIM-1 and Nephrin was positive and ,the ROC analysis of KIM-1 show high sensitivity and specificity (93.3%, 99.3%).conclusion: kim-1 and nephrin used for diagnosis diabetic nephropathy disease and more sensitivity and specificity from other markers and used to detect kidney disease without clear clinical signs.

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