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Article Type

Original Study

Abstract

Background: The most frequent cause of death for females with gynecological cancer diagnoses is ovarian cancer (OC). Furthermore, generally speaking, it ranks as the 5th most frequent cause of death for females. The majority of cases had advanced diagnoses, which worsens the disease's prognosis. Objectives: The aims of the study is to Estimate the immunological markers “cytotoxic T lymphocyte associated antigen 4” (CTLA4) and “Vascular Endothelial Growth Factor” (VEGF) in Adjuvant women (OC). Materials and methods: 90 Adjuvant women OC were included in this study (30 of them were taking (1-6) dose of biotherapy Bevacizumab (Avastin) Group 1 (G1), 30 of them were taking (> 6) dose of avastin Group 2 (G2), and the last 30 taking chemotherapy Group 3 (G3) in addition to 40were healthy used as control group. The “Quantitative measurement by Enzyme-linked immunosorbent assay” (ELISA) of human were used to estimate the immunological marker (CTLA4 and VEGF). Results: High significance difference at (P = 0.001) between the means age and occupation of OC studied groups while no significant difference at (P value = 0.4 and 0.3) between the means of residency and body mass index (BMI) in studied groups. However, the significant difference at (P value = 0.04) between the mean of family history in studied groups. High significant difference between studied groups and the control group for CTLA4 and VEGF at (P value < 0.001) also in Receiver operative characteristic Curve (ROC) The presence of CTLA4 and VEGF were highly significant difference of all studied groups (G1, G2 and G3). with elevated of sensitivity and specificity of CTLA4 (80 and 86.67 in G1, 76.6 and 86.6 in G2 and 80 and 86.67 in G3 respectively), Also higher sensitivity and specificity of VEGF (60 and 93.9 in G1, 80 and 100 in G2, and 73.3 and 100 in G3 respectively), also the correlation between levels of CTLA4 with VEGF were highly significance in G1 and G2, but no significant correlations in G3 at (P = 0.0001, 0.0003 and 0.088 respectively). Conclusion: The studied parameters may play an important role for the evaluation of therapeutic response on adjuvant OC women patients.

Keywords

Ovarian cancer, CTLA4, VEGF, Biotherapy, Avastin, Chemotherapy

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