Insights into the Role of Microbial Infection in Recurrent Aphthous Stomatitis

Authors

Alaa W. Izzat, Department of Oral Diagnostic Sciences, College of Dentistry, University of Baghdad, Baghdad, IraqFollow
Batool Hassan Al-Ghurabi, Department of Basic Science, College of Dentistry, University of Baghdad, Baghdad, IraqFollow
Lina Sami Adham, Department of Basic Science, College of Dentistry, University of Baghdad, Baghdad, Iraq

Article Type

Review

Abstract

Ulcers that form in the oral mucosa are a hallmark of recurrent aphthous stomatitis (RAS), a chronic inflammatory disease. Up to 25% of the population may get aphthous ulcers, and recurrence rates within three months can reach 50%. Among women, it is more prevalent. Although the precise cause of RAS is not yet known, studies have shown that infections caused by microbes may be a major factor in the development of the disease. Infections caused by microorganisms have a complicated and multifaceted function in RAS, influencing the human immune system, the oral microbiota, and environmental variables. The purpose of this review is to provide light on how viruses and bacteria contribute to the development of RAS.

Keywords

Recurrent aphthous stomatitis, Microbiota, Bacterial infection, Viral infection

Recommended Citation

Izzat, Alaa W.; Al-Ghurabi, Batool Hassan; and Adham, Lina Sami (2025) "Insights into the Role of Microbial Infection in Recurrent Aphthous Stomatitis," Al-Esraa University College Journal for Medical Sciences: Vol. 6: Iss. 10, Article 5.
DOI: https://doi.org/10.70080/2790-7937.1057