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Article Type

Review

Abstract

Tooth extraction initiates a cascade of biological changes that result in alveolar bone resorption, compromising both the esthetic and functional outcomes of future dental rehabilitations, particularly implant placement. Socket preservation strategies have emerged as crucial interventions aimed at minimizing post-extraction ridge collapse. This review explores the synergistic effects of injectable platelet-rich fibrin (I-PRF) and collagen plugs in enhancing socket preservation outcomes. Collagen plugs serve as biocompatible scaffolds, promoting hemostasis, cellular migration, and angiogenesis, while supporting soft tissue healing and bone regeneration. Concurrently, I-PRF-an autologous, growth factor-rich biomaterial-provides a dynamic reservoir of platelets, leukocytes, and key cytokines such as Platelet-Derived Growth Factor (PDGF), p. Transforming Growth Factor-beta (TGF-β), p. and Vascular Endothelial Growth Factor (VEGF), p. which collectively accelerate tissue regeneration and vascularization. The injectable form allows for versatile application, either alone or in combination with grafting materials. This review highlights current evidence on the biological mechanisms and clinical benefits of combining I-PRF with collagen plugs for socket preservation, demonstrating promising potential for improved ridge maintenance and accelerated healing in post-extraction sites.

Keywords

Socket preservation, socket dimensions, alveolar bone loss, collagen plug, injectable platelet concentrat

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