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Article Type

Original Study

Abstract

Background: Hypothyroidism is a common medical condition that occurs due to a lack of the hormone thyroxine. Hashimoto's thyroiditis (HT) is the most prevalent thyroid disorder, also known as autoimmune thyroid disease (AITD). Approximately 20-30% of people develop hypothyroidism due to ongoing inflammation of the thyroid tissue it triggers. Aims: To investigate the difference between inflammatory and biochemical test in Hashimoto autoimmune thyroiditis (AITD) and hypothyroidism patients (non-autoimmune) Methods: The study was done on 50 Hashimotos patients, 50 Hypothyroidism patients from the Endocrinology Unit at Baghdad Teaching Hospital and Educational Laboratories / Baghdad City, Iraq, and 50 control healthy subjects during the first half of the year 2024, from 7th January until 25th August 2024. Results: The mean BMI of the HT group was (33.07±4.6) and for hypothyroidism group was (31.92±3.0), did not show statistically significant differences (p=0.293). However, the mean BMI of both groups differed highly statistically significant (p≤0.001) when compared to that of the control group (21.72±1.43). Median serum levels of cholesterol in HT was (54.7) while in hypothyroidism was (47.9) while for the control group was (15.1), the p-value for the three groups was (≤0.001) and showed highly significant differences. Calcium median results were (0.86) for HT, (0.91) for hypothyroidism patients while (0.95) for control group all were highly significant statically (≤0.001). Finally, CRP showed highly statistically significant difference (p≤0.001) when the levels of these parameters were compared among Hashimoto group, hypothyroidism group, and control group with median range in HT (11.2), hypothyroidism (6.2) and control group (1.91). Conclusions: BMI had no significant differences between HT and hypothyroidism group but the two groups were different significantly from the control group, CRPL3, CA, Cholesterol all were different significantly between HT, Hypothyroidism and control group.

Keywords

HT, Thyroxine, AITD, Indirect immunofluorescence, CRP, Ca

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