Immunological and Molecular Investigation of Non-Helicobacter pylori Gastritis within Type 2 Diabetes Mellitus

Authors

Zahraa Maad Abdul-Sahib, Pathological Analysis Lab., Jazani Al-Imam Health Centre, Al-Khalis Sector for Primary Health Care, Diyala, IraqFollow
Najah Ali Mohammad, Health Department, Medical Technical Institute, Baghdad, Iraq
Abdul Razzaq Nema, Department of Medical Lab. Tech., College of Health and Medical Tech., Middle Technical University. Baghdad, Iraq

Article Type

Original Study

Abstract

Gastritis is one of the most common diseases in the digestive system, especially in patients with low immunity, including diabetic mellitus. Diabetic Mellitus considered one of an endocrine gland disease characterized by elevated blood sugar because of a defect in the regulation of sugar in the body. The purpose of this study was to assess the association between Non-Helicobacter pylori gastritis with type 2 diabetic mellitus (N-Hp G.T2DM), by interleukin IL-10 and IL-18. This study included 37(41.1%) N-Hp G.T2DM, 23 (25.6%) gastritis (G) only and 30 (33.3%) healthy participants. Biomarkers for T2DM and G (FBS, HbA1c and BMI) along with H.pylori IgG Ab and hs-CRP evaluated. Additionally, levels of IL-10 and IL-18 evaluated by both ELSIA and real time PCR .Through the study; we noticed a correlation between N-Hp G.T2DM patients and patients with G. We discovered that N-Hp G. T2DM associated had lower levels of Il-10 than gastritis (pHpG.DM than in gastritis (p<0.0001).

Keywords

Non-H.pylori gastritis, T2DM, ELISA, Real time Polymerase Chain Reaction

Recommended Citation

Abdul-Sahib, Zahraa Maad; Mohammad, Najah Ali; and Nema, Abdul Razzaq (2024) "Immunological and Molecular Investigation of Non-Helicobacter pylori Gastritis within Type 2 Diabetes Mellitus," Al-Esraa University College Journal for Medical Sciences: Vol. 5: Iss. 8, Article 11.
DOI: https://doi.org/10.70080/2790-7937.1043