Relationship of Serum Copeptin Level with Traditional Risk Factors for Acute Coronary Syndrome in Early Diagnosis of this Syndrome in Iraqi Patients

Authors

Ali Abdul Rasool Hussein, Department of Chemistry and Biochemistry, College of Medicine, Mustansiriyah University, Baghdad, IraqFollow
Abdulkareem H. Issa, Department of Chemistry and Biochemistry, College of Medicine, Mustansiriyah University, Baghdad, Iraq
Abbas Naji Muslem Al Shareeifi, Department of Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq

Article Type

Original Study

Abstract

Background: Acute coronary syndrome (ACS) is still one of the main causes of morbidity and mortality worldwide and an early diagnosis of myocardial infarction (MI) aims to decrease mortality in MI patients. The ACS is manifested as one of three subtypes. These subtypes include MI with the electrocardiogram (ECG) is showing ST-segment elevation (STEMI), the other is MI with the ECG is showing no ST-segment elevation (NSTEMI) and the third type is unstable angina (UA). Objectives: To explore the Relationship of serum copeptin level with traditional risk factors for acute coronary syndrome in early diagnosis of this syndrome in Iraqi patients.

Methodology: 120 patients “72 males and 48 females”, aged ≥ 30 years were consecutively selected from those who were admitted and diagnosed as ACS. The ACS patients were of three subtypes; STEMI, NSTEMI and UA and apparently healthy subjects were recruited as controls for this study. For each study subject, serum Copeptin, FBS, cholesterol and GOT levels were measured. Results: The copeptin level remained significant higher level in presence or absence of any of the studied risk factors .The CPP mean level showed an overall significant difference among study groups, copeptin mean level was significantly higher in each ACS subgroup than in controls group (P < 0.001).

Conclusion: Serum copeptin level remained significantly higher in ACS subgroups than in controls group in the first hurs. After onset of chest pain in presence or absence of any of the studied risk factors of ACS.

Keywords

Acute coronary syndrome, STEMI, Copeptin, Traditional risk factors, UA, NSTEMI

Recommended Citation

Hussein, Ali Abdul Rasool; Issa, Abdulkareem H.; and Al Shareeifi, Abbas Naji Muslem (2024) "Relationship of Serum Copeptin Level with Traditional Risk Factors for Acute Coronary Syndrome in Early Diagnosis of this Syndrome in Iraqi Patients," Al-Esraa University College Journal for Medical Sciences: Vol. 5: Iss. 8, Article 3.
DOI: https://doi.org/10.70080/2790-7937.1035