Article Type
Original Study
Abstract
Background: Coronary atherosclerosis is a long lasting and continuously evolving disease with multiple clinical manifestations ranging from asymptomatic to stable angina, acute coronary syndrome (ACS), heart failure (HF) and sudden cardiac death (SCD). The onset and advancement of coronary atherosclerosis are influenced by both genetic and environmental factors. Objectives: The study aimed to find out if cathepsin D a good indicator to diagnose atherosclerosis and cardiovascular diseases and its relation with lipid profile. Materials and Methods: The study conducted with the participation of 150 subjects (100 patients with coronary atherosclerosis and 50 healthy control). Age for all subject was in range 40-70 years. All participants were subjected for laboratory measurement of cathepsin D level by Enzyme-Linked Immunosorbent Assay (ELISA), and lipid profile parameters by using manual kits. Results: There are significant elevation in the levels of both cathepsin D (P =Conclusion: Cathepsin D can be used as a good indicator for detecting coronary atherosclerosis along with high levels of lipid profile parameters ( and low levels of high density lipoprotein) in comparison to healthy control.
Keywords
Coronary atherosclerosis, Cathepsin D, Lipid profile, Catheterization, Cardiovascular diseases
Recommended Citation
Salim, Israa Saad; Jassim, Walaa Ismael; and Hassan, Ahmed Saadi
(2024)
"Cathepsin D and Its Relation with Lipid Profile in Coronary Atherosclerosis Patients,"
Al-Esraa University College Journal for Medical Sciences: Vol. 5:
Iss.
8, Article 5.
DOI: https://doi.org/10.70080/2790-7937.1037