Article Type
Original Study
Abstract
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease, with about 15-20% of patients being children. The causes of the disease are a mix of genetic and environmental factors. Complement C3 and C4 play a significant role in the diagnosis and monitoring of disease severity. Additionally, renal function tests are important for monitoring the disease, as the disease affects the kidneys in a large percentage of patients. Aim: The study was primarily conducted to compare complement C3 and C4 levels in Iraqi adult and juvenile patients with systemic lupus erythematosus. Patient and methods: The study consisted of 70 patients, 35 children and 35 adults, in addition to 30 individuals as a control group. The patients visited the Rheumatology Clinic at Baghdad Hospital and the Nephrology Clinic at the Children’s Welfare Hospital in Medical City, Baghdad, during the period between January and May 2024. Human C3 and C4 tests was measured by Immunoturbidimetric assay by using Roche/Hitachi cobas C311 analyzer. Results: Complement levels were low in both groups, but more notice in juveniles, particularly complement C3 pConclusion: Measuring complement levels, kidney function, and blood counts is crucial in the regular monitoring of patients, as these tests are related to disease assessment and the development of an appropriate treatment plan.
Keywords
Juvenile-onset SLE, Adult onset SLE, Complements system
Recommended Citation
Aldhahir, Sahar S.; Al-Rayahi, Izzat A. M.; and Muhsin, Salwa S.
(2024)
"Complement Component C3 and C4 Levels in Juvenile and Adult SLE Iraqi Patients,"
Al-Esraa University College Journal for Medical Sciences: Vol. 5:
Iss.
8, Article 9.
DOI: https://doi.org/10.70080/2790-7937.1041